NeuroMind BioPharma

Supercritical CO2

Our Process

Supercritical CO2 has low surface tension and viscosity and therefore high mass transfer rates can be achieved, providing ideal conditions for extracting compounds with a high degree of recovery in a short period of time and with easy separation of products.

Carbon dioxide has attracted a negative image as a “Greenhouse gas” over the last few years but it can be successfully used as a highly tunable solvent to replace traditional petrochemical solvents. Carbon dioxide is generated from many everyday activities but the growth in the production of biofuels such as bioethanol provides an economic and sustainable supply of high purity CO2. The use of liquid or supercritical CO2 provides an alternative to conventional organic solvents in a wide range of applications including extraction and fractionation of botanical materials, reactions with conventional or bio-catalysts, product cleaning and the production of micro particles. As a solvent, CO2 is universally considered as a clean, green solvent and can be used for the preparation of “organic” extracts in many countries.

Carbon dioxide can be used in the liquid (sub-critical) or supercritical state. A supercritical fluid is a substance above its critical temperature (Tc) and pressure (Pc) which for CO2 is 304 K (31.1 °C) and 7.4 MPa (73.8 bar), making the supercritical phase easily accessible compared to other solvents. Supercritical CO2 has properties that are intermediate between gaseous and liquid CO2 exhibiting both high diffusivity and low viscosity with variable density and polarity achieved through changing pressure and temperature.

We are setting a pharmaceutical standard for natural product extraction which will be made available to regulators.